TMS Safety & Effectiveness

Clinical trials have demonstrated the safety of TMS therapy in treating patients who have had an inadequate response to prior antidepressant medications.  Cascade TMS in Portland, OR has been at the forefront of TMS safety and is our number one concern.

Treatment with TMS therapy caused very few side effects.  It is generally well tolerated by patients. The most common side effect reported during clinical trials was scalp discomfort—generally mild to moderate and occurring less frequently after the first week of treatment.

Fewer than 5% of patients discontinued treatment with TMS therapy due to adverse events.

Over 10,000 active treatments were performed across all TMS clinical trials demonstrating its safety. Most common side effects include scalp discomfort or headache.

  • No systemic side effects
  • No weight gain
  • No sexual dysfunction
  • No sedation
  • No nausea
  • No dry mouth
  • No adverse effects on concentration or memory
  • No drug interactions

TMS Therapy should not be used in patients with implanted metallic devices or non-removable metallic objects in or around the head. This does not include metallic fillings in teeth.

TMS therapy should not be used in patients with implants controlled by physiological signals. This includes pacemakers, implantable cardioverter defibrillators (ICDs), and vagus nerve stimulators (VNS).



Janicak, P, et al. Transcranial Magnetic Stimulation (TMS) in the Treatment of Major Depression: A Comprehensive Summary of Safety Experience from Acute Exposure, Extended Exposure and During Reintroduction Treatment. Journal of Clinical Psychiatry, February 2008.